Steven W. Cole, Ph.D. - biographical sketch
Associate Professor, Division of Hematology-Oncology, Department of
Medicine, UCLA School of Medicine
Associate Member, UCLA/DOE Molecular Biology Institute
Associate Member, Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior

Research Interests

Dr. Cole studies the molecular mechanisms by which the nervous system controls viral and human gene expression. Much of his research focuses on HIV infection, including epidemiologic studies of psychological risk factors, clinical studies on the autonomic nervous system’s effect on disease pathogenesis, and in vitro studies on the molecular signaling pathways by which neurotransmitters accelerate HIV replication. Other projects analyze neural control of Human Herpesvirus 8 (Kaposi’s Sarcoma herpesvirus) and cytokine production by dendritic cells (IL-12 and Interferon-alpha). He recently developed a new vaccine vector that capitalizes on PNI signaling principles to enhance cytotoxic T cell responses to viral infections and tumors. His present studies use novel bioinformatic and statistical genetics tools to enhance the effectiveness of these vectors in the search for an AIDS vaccine.

Recent publications

Sloan EK, Capitanio JP, Tarara RP, Mendoza SP, Mason WA, Cole SW.                Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. J Neurosci. 2007 Aug 15;27(33):8857-65.
PMID: 17699667 [PubMed - indexed for MEDLINE]

 

Sloan EK, Capitanio JP, Cole SW.  Stress-induced remodeling of lymphoid innervation. Brain Behav Immun. 2007 Aug 11; [Epub ahead of print]
PMID: 17697764 [PubMed - as supplied by publisher]

 

Sloan, E. K., Tarara, R. P., Capitanio, J. P., & Cole, S. W. (2006)  Enhanced SIV replication adjacent to catecholaminergic varicosities in primate lymph nodes.  Journal of Virology, 80, 4326-4335.

 

Sood, A. K., Bhatty, R. Kamat, A. A., Landen, C. N., Han, L., Thaker, P. H., Li, Y., Gershenson, D. M., Lutgendorf, S., and Cole, S. W. (2005)  Stress hormone-mediated invasion of ovarian cancer cells.  Clinical Cancer Research, 12, 369-375.

 

Nilsson MB, Armaiz-Pena G, Takahashi R, Lin YG, Trevino J, Li Y, Jennings N, Arevalo J, Lutgendorf SK, Gallick GE, Sanguino AM, Lopez-Berestein G, Cole SW, Sood AK.    Stress hormones regulate IL-6 expression by human ovarian carcinoma cells through a SRC-dependent mechanism.
J Biol Chem. 2007 Aug 23; [Epub ahead of print]

 

 

Capitanio JP, Abel K, Mendoza SP, Blozis SA, McChesney MB, Cole SW, Mason WA.    Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease. Brain Behav Immun. 2007 Aug 22; [Epub ahead of print]

 

Beale IL, Kato PM, Marin-Bowling VM, Guthrie N, Cole SW. Improvement in cancer-related knowledge following use of a psychoeducational video game for adolescents and young adults with cancer. J Adolesc Health. 2007 Sep;41(3):263-70. Epub 2007 Jul 12.
PMID: 17707296 [PubMed - in process]

 

Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., and Sood, A. K. (2005)  The Influence of Biobehavioral Factors on Tumor Biology: Pathways and Mechanisms.  Nature Reviews Cancer, 6, 240-248.

 

Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT.  Social regulation of gene expression in human leukocytes. Genome Biol. 2007 Sep 13;8(9):R189 [Epub ahead of print]

 

Cole, S. W., Yan, W., Galic, Z., Arevalo, J., & Zack, J. A. (2005)  Expression-based monitoring of transcription factor activity:  The TELiS database.  Bioinformatics, 21, 803-810.

 

Cole, Steven W.
Med-Hemat & Onc
11-934 Factor
mail code: 167817
phone: 310-267-4243
fax: 310-825-6192
email: coles@ucla.edu