Anthony W. Butch, Ph.D. - Biographical Sketch
Associate Professor, Department of Pathology & Lab Medicine, UCLA Medical Center, Los Angeles, CA.
Director of Chemistry, Toxicology, Immunochemistry, and Support Services,
Clinical Laboratories at the UCLA Medical Center, Los Angeles, CA.
Director of Clinical Immunology Research Labs, UCLA Medical Center, Los Angeles, CA.
Associate Member, Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior

Research Interests

Dr. Butch is interested in understanding how antigen-presenting dendritic cells regulate immunity and inflammatory responses in various microenvironments.

Earlier work investigated molecular mechanisms by which human follicular dendritic cells regulate T cell responses in germinal centers of lymphoid tissue. Collaborative studies are currently underway with Dr. Kelly to evaluate the role of dendritic cells in generating immunity in various mucosal tissues using a mouse model of Chyamydia infection. Other areas of research involve the characterization of assays to evaluate immune function and the development of immuoassays against novel proteins. Recent work in collaboration with Dr. Gatti has resulted in the development of a sandwich immunoassay to quantitate cellular levels of the ataxia-telangiectasia mutated (ATM) protein. ATM protein is absent or found in extremely small quantities in mononuclear cells from patients with the progressive neurodegenerative disorder ataxia-telangiectasia.

Recent Publications

 

Monchamp T, Chopra IJ, Wah DT, Butch AW.  
Falsely elevated thyroid hormone levels due to anti-sheep antibody interference in an automated electrochemiluminescent immunoassay.
Thyroid. 2007 Mar;17(3):271-5.
PMID: 17381362 [PubMed - indexed for MEDLINE]

 

Nguyen MK, Ornekian V, Butch AW, Kurtz I.     
A new method for determining plasma water content: application in pseudohyponatremia. Am J Physiol Renal Physiol. 2007 May;292(5):F1652-6. Epub 2007 Feb 13. PMID: 17299138 [PubMed - indexed for MEDLINE]

 

Kelly KA, Butch AW.             
Antigen-specific immunoglobulin E+ B cells are preferentially localized within germinal centres. Immunology. 2007 Mar;120(3):345-53. Epub 2006 Dec 1. PMID: 17163956 [PubMed - indexed for MEDLINE]

 

 

Leppert JT, Lam JS, Butch AW, Belldegrun AS. Are testosterone immunoassays reliable for monitoring anti-androgen therapy? Urol Oncol. 2006;24:277-8.

 

Wah DT, Wises PK, Butch AW.           
Analytic performance of the iQ200 automated urine microscopy analyzer and comparison with manual counts using Fuchs-Rosenthal cell chambers.
Am J Clin Pathol. 2005 Feb;123(2):290-6. PMID: 15842056 [PubMed - indexed for MEDLINE]

 

Jahr JS, Osgood S, Rothenberg SJ, Li QL, Butch AW, Gunther R, Cheung A, Driessen B.         
Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure, and Hemolink). Anesth Analg. 2005 Feb;100(2):431-6.
PMID: 15673871 [PubMed - indexed for MEDLINE]

 

Anthony W. Butch
UCLA Medical Center
Department of Pathology & Lab Medicine
10833 Le Conte Ave, A7-149 CHS
Los Angeles, CA 90095-1713
310-206-0587 (Tel)
310-794-4864 (Fax)
abutch@mednet.ucla.edu